Tizanidine

Zanaflex® (tizanidine hydrochloride) is a centrally acting α2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol; solubility in water decreases as the pH increases. Its chemical name is 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiodiazole hydrochloride. Tizanidine's molecular formula is C9H8CIN5 S-HCl, its molecular weight is 290.2 and its structural formula is:


Zanaflex Capsules™ (tizanidine) are supplied as 2, 4, and 6 mg capsules and Zanaflex (tizanidine) ® tablets are supplied as 2 and 4 mg tablets for oral administration. Zanaflex (tizanidine) Capsules™ are composed of the active ingredient, tizanidine hydrochloride (2.29 mg equivalent to 2 mg tizanidine base, 4.58 mg equivalent to 4 mg tizanidine base, and 6.87 mg equivalent to 6 mg tizanidine base), and the inactive ingredients, hydroxypropyl methyl cellulose, silicon dioxide, sugar spheres, titanium dioxide, gelatin, and colorants.

Zanaflex (tizanidine) ® tablets are composed of the active ingredient, tizanidine hydrochloride (2.29 mg equivalent to 2 mg tizanidine base and 4.58 mg equivalent to 4 mg tizanidine base), and the inactive ingredients, silicon dioxide colloidal, stearic acid, microcrystalline cellulose and anhydrous lactose.

What is tizanidine (Zanaflex)?

Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.

Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.

Tizanidine may also be used for purposes other than those listed in this medication guide.

Tizanidine 2 mg-PAR

oval, white, imprinted with R179

What are the possible side effects of tizanidine (Zanaflex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

    feeling light-headed, fainting, slow heart rate;

    hallucinations, confusion, unusual thoughts or behavior;

    nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

    burning or pain when you urinate.

Less serious side effects may be more likely to occur, such as:

•     drowsiness or dizziness;

•     feeling anxious or nervous;

•     numbness or tingling;

•     stomach pain, diarrhea, constipation, vomiting;

•     fever;

•     dry mouth;

•     muscle weakness, back pain;

•     increased muscle tone or spasms; or

•     sweating or skin rash.

What is the most important information I should know about tizanidine (Zanaflex)?

Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.

Do not take tizanidine if you are also taking the antidepressant fluvoxamine (Luvox), or the antibiotic ciprofloxacin (Cipro).

Do not use tizanidine at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Switching between tizanidine tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.

Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of this medication can damage your liver.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with tizanidine.

Avoid drinking alcohol. It can increase some of the side effects of tizanidine.

What are the possible side effects of tizanidine 

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